Myeloproliferative disorders are diseases in which the bone marrow produces too many of one of the three types of blood cells:
Red blood cells, which carry oxygen to all the tissues in the body
White blood cells, which fight infection
Platelets, which makes blood clot
Thrombocythemia, also called primary or essential thrombocythemia, is a myeloproliferative disorder. It is characterized by the production of too many platelets in the bone marrow. Too many platelets make normal clotting of blood difficult. This can result in too much clotting, or not enough clotting.
There may be no single cause for thrombocythemia. It is believed to be caused by mutations to megakaryocytes, the platelet-making cells in the bone marrow.
The following are the most common symptoms of thrombocythemia. However, each individual may experience symptoms differently. Symptoms may include:
The symptoms of thrombocythemia may resemble other blood disorders or medical problems. Always consult your doctor for a diagnosis.
In addition to a complete medical history and physical examination, diagnostic procedures for thrombocythemia may include blood tests to measure blood counts, and a blood smear to further assess your platelets. Excluding other causes of reactive thrombocytosis as well as other myeloproliferative disorders is important in the workup. Bone marrow biopsy (the marrow may be removed by aspiration or a needle biopsy under local anesthesia) may also be necessary.
Specific treatment for thrombocythemia will be determined by your doctor based on:
Treatment may include:
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