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Relationship Between Augmentation Pressure and LDL Cholesterol Levels In Normotensive Subjects

Sofya Kostanyan, Inna Nelipovich, Mark Balek, Tarek Mousa, Karen Ngai, Susan Ingenito, Olakunle Akinboboye

Augmentation pressure (AP) is the contribution that pressure wave reflection makes to systolic arterial pressure and it is an indirect measure of arterial stiffness. We hypothesized that there is a relationship between AP and LDL cholesterol levels in normotensive individuals.  The objectives of the study were to compare AP between normotensive subjects with LDL ≥130 mg/dl vs. <130 mg/dl and to examine the relationship between LDL and AP.

Methods: We recruited 53 healthy individuals (including 35F mean age 62±3). Patients with established heart disease or hypertension were excluded. Pressure waveforms were recorded from the radial artery and corresponding central waveforms were generated using validated transfer function (SphygmoCor System software, AtCor Medical, Inc.). Augmentation pressure was derived from the central pressure waveforms.  Fasting lipid levels were also measured. Subjects were subdivided into 2 groups: (A) those with LDL less than 130 and (B) those with LDL greater than 130

Results: Group A comprised 33 subjects with mean LDL of 101 ±19 and group B comprised 20 subjects with mean LDL of 145±11. Mean AP was significantly less in group A than B (6± 4 Vs. 8± 6, p =0.02). In addition, we found a significant linear relationship between LDL and AP (R= 0.3, p= 0.04) (see figure below) 

Conclusion: Augmentation pressures are significantly higher in subjects with LDL >130 mg/dl than in those with LDL < 130 mg/dl suggestive of higher vascular stiffness in the former. In addition augmentation pressure correlates linearly with serum LDL cholesterol levels.

 
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