Characteristics and Survival Data of Cerebellar Glioblastoma Multiforme: An Analysis of Data From the Surveillance, Epidemiology, and End Results (SEER) Registry
Alicia E. Gittleman, M.D., Himanshu Nagar, B.S., Dattatreyudu Nori, M.D.
Objective: Glioblastoma multiforme (GBM) is the most common primary central nervous system tumor in adults, comprising approximately 50% of all primary intracranial tumors. These aggressive, infiltrating tumors generally occur in the fifth and sixth decades of life, and are associated with a dismal prognosis. They have a predilection for the deep white or gray matter, primarily in the cerebral hemispheres. Primary cerebellar GBM is a rare tumor, and accounts for approximately 1% of all cases of GBMs. Because of its rarity, little is known about these tumors. The aim of the present study is to describe the characteristics and the overall survival of patients with cerebellar GBMs.
Methods and Materials: The Surveillance, Epidemiology, and End Results (SEER) Registry database (1994-2003) was queried for cases of cerebellar GBMs. A retrospective analysis was performed on 206 cases
Results: Of 206 patients reviewed, 191 (88%) were Caucasian, 12 (6%) were African-American, and 13 (6%) were other. There were more male patients than female patients, with 127 (62%) of patients being male and 79 (38%) of patients being female. The mean age of patients was 53.5 years. The overall survival time was 13.03 months.
Conclusions: Like cerebral GBMs, Caucasians are more frequently diagnosed than those of another race. Similarly, there is a propensity for more males to be afflicted than females. The mean age of patients is slightly lower with cerebellar GBMs than with cerebral GBMs, and the overall survival time is slightly longer with cerebellar GBMs than with cerebral GBMs. Detailed multivariate analysis to identify prognostic factors will be presented at the time of the meeting.